This altarpiece was partially destroyed during the 1755 earthquake. It is composed of 1,498 tiles in a multitude of hues. The top section with missing pieces is the Annunciation. The Adoration panel in the center is flanked by the images of St. Luke on the left and St. John on the right. The arrangement of this altarpiece resembles that of a retablo. It is attributed to Marçal de Matos, one of the masters of Portuguese azulejo painting.